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Compare	Tesamorelin The only FDA-approved GHRH analog — proven against belly fat.	Sermorelin The first 29 amino acids of natural GHRH — once an FDA-approved drug.
Category	Growth Hormone Axis	Growth Hormone Axis
Evidence	5/5Phase 3 RCTs in HIV lipodystrophy led to FDA approval; off-label populations less studied.	4/5Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older.
FDA status	FDA-approved (Egrifta, 2010)	Formerly FDA-approved (Geref) — discontinued 2008
WADA (sport)	Banned	Banned
Also known as	Egrifta, TH9507	Geref, GRF 1-29 NH2, Sermorelin acetate
How it works	Stimulates pituitary GH release through the GHRH receptor, raising IGF-1 and reducing visceral adipose tissue while preserving the natural pulse pattern.	Binds the GHRH receptor on the pituitary, triggering a short pulse of growth hormone and a rise in IGF-1. The body's normal feedback (somatostatin) still applies, so levels stay within a more natural range than injected GH.
Half-life	About 25–40 minutes	About 10–20 minutes; the GH pulse lasts a few hours
Commonly reported doses	Label dose (Egrifta SV): 2 mg, once daily Community low-dose: 1 mg, once daily, bedtime	Community: 300 mcg, once daily at bedtime
Route	Subcutaneous, abdomen	Subcutaneous
Good once mixed	~14 days in the fridge	~21 days in the fridge
Top side effects	Joint pain Swelling of hands/feet Injection-site reactions	Facial flushing right after injection Injection-site pain, redness or swelling Headache
Lowest price per mg	$4.20 (10 mg vial, 40% off)	$3.60 (10 mg vial, 40% off)
Latest lab purity	99.61% (lot TES0003)	99.15% (lot SER0001)
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