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Cognitive & Mood
A small angiotensin-derived compound with striking rat memory data and no human trials.
Cognitive & Mood
A modified Semax sold only as a ready-made nasal spray. Evidence is borrowed from Semax.
Dihexa is not FDA-approved and rated 2/5 for evidence; Adamax is not FDA-approved and rated 1/5. Dihexa has more human evidence behind it. Both are banned in sport by WADA. Both are used for cognitive & mood goals.
| Compare | Dihexa A small angiotensin-derived compound with striking rat memory data and no human trials. | Adamax A modified Semax sold only as a ready-made nasal spray. Evidence is borrowed from Semax. |
|---|---|---|
| Category | Cognitive & Mood | Cognitive & Mood |
| Evidence | 2/5Animal and cell data from one main research group. No published human trials. A related HGF-boosting drug from the same lineage (fosgonimeton) missed its main goal in a Phase 2/3 Alzheimer's trial. | 1/5No published research on Adamax. Effects are inferred from Semax, which has small Russian clinical studies. |
| FDA status | Not FDA-approved | Not FDA-approved |
| WADA (sport) | Banned | Banned |
| Also known as | PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide | Adamax Research Mist, N-acetyl Semax analog |
| How it works | Binds hepatocyte growth factor (HGF) and strengthens its signal through the c-Met receptor, promoting new synapses and dendritic spines. HGF/c-Met is also a well-known cancer-growth pathway. | Assumed to work like Semax: raising BDNF and modulating dopamine and serotonin signaling. Whether the modifications change potency or duration has not been tested. |
| Half-life | Not established in humans | Unknown; marketed as longer-acting than Semax, unproven |
| Commonly reported doses |
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| Route | Oral or transdermal (most common); some inject | Intranasal |
| Good once mixed | ~14 days in the fridge | Ready-made spray |
| Top side effects |
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| Lowest research-listing price per mg | $3.60 (10 mg vial, 40% off) | $3.60 (15 mg vial, 40% off) |
| Latest lab purity | 99.54% (lot DHX0001) | 99.10% (lot SADM0001) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Dihexa is not FDA-approved and rated 2/5 for evidence; Adamax is not FDA-approved and rated 1/5. Dihexa has more human evidence behind it. Both are banned in sport by WADA. Both are used for cognitive & mood goals.
Dihexa: Not FDA-approved. Adamax: Not FDA-approved. Regulations change, so confirm with the FDA.
Dihexa is rated 2 out of 5: Animal and cell data from one main research group. No published human trials. A related HGF-boosting drug from the same lineage (fosgonimeton) missed its main goal in a Phase 2/3 Alzheimer's trial. Adamax is rated 1 out of 5: No published research on Adamax. Effects are inferred from Semax, which has small Russian clinical studies. The scale is explained on our methodology page.
Dihexa is banned by WADA, by name or as part of a named class. Adamax is banned by WADA, by name or as part of a named class.