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Metabolic & Weight
The GLP-1 drug that started the modern weight-loss era: Ozempic and Wegovy.
Metabolic & Weight
A small-molecule NNMT blocker with mouse data only — not actually a peptide.
Semaglutide is FDA-approved and rated 5/5 for evidence; 5-Amino-1MQ is not FDA-approved and rated 2/5. Semaglutide has more human evidence behind it. 5-Amino-1MQ is banned in sport by WADA; Semaglutide is not. Both are used for metabolic & weight goals.
| Compare | Semaglutide The GLP-1 drug that started the modern weight-loss era: Ozempic and Wegovy. | 5-Amino-1MQ A small-molecule NNMT blocker with mouse data only — not actually a peptide. |
|---|---|---|
| Category | Metabolic & Weight | Metabolic & Weight |
| Evidence | 5/5FDA-approved with large RCT programs (SUSTAIN, STEP, SELECT). SELECT showed a 20% reduction in major cardiovascular events in people with heart disease and overweight. | 2/5Cell studies and a small number of mouse studies; no published human trials. |
| FDA status | FDA-approved (Ozempic 2017, Wegovy 2021) | Not FDA-approved |
| WADA (sport) | Not on the Prohibited List | Banned |
| Also known as | Ozempic, Wegovy, Rybelsus, NN9535, AMP-1 (SM) | 5-amino-1-methylquinolinium, NNMT inhibitor |
| How it works | A modified version of the natural hormone GLP-1 with a fatty-acid side chain that binds albumin, stretching its half-life to about a week. It lowers appetite through the brain, slows stomach emptying, and increases insulin release when blood sugar is high. | Inhibits nicotinamide N-methyltransferase (NNMT). Less NNMT activity is thought to preserve NAD+ and SAM (a methyl donor) inside fat cells, nudging them to burn more energy and store less fat. This is based on cell and mouse work. |
| Half-life | About 7 days (once-weekly dosing) | Not established in humans |
| Commonly reported doses |
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| Route | Subcutaneous (abdomen, thigh, upper arm) | Subcutaneous |
| Good once mixed | ~28 days in the fridge | ~28 days in the fridge |
| Top side effects |
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| Lowest research-listing price per mg | $3.00 (10 mg vial, 40% off) | $0.60 (50 mg vial, 40% off) |
| Latest lab purity | 99.90% (lot SEM0002) | 99.97% (lot AMQ0002) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Semaglutide is FDA-approved and rated 5/5 for evidence; 5-Amino-1MQ is not FDA-approved and rated 2/5. Semaglutide has more human evidence behind it. 5-Amino-1MQ is banned in sport by WADA; Semaglutide is not. Both are used for metabolic & weight goals.
Semaglutide: FDA-approved (Ozempic 2017, Wegovy 2021). 5-Amino-1MQ: Not FDA-approved. Regulations change, so confirm with the FDA.
Semaglutide is rated 5 out of 5: FDA-approved with large RCT programs (SUSTAIN, STEP, SELECT). SELECT showed a 20% reduction in major cardiovascular events in people with heart disease and overweight. 5-Amino-1MQ is rated 2 out of 5: Cell studies and a small number of mouse studies; no published human trials. The scale is explained on our methodology page.
Semaglutide is not named on the WADA list, though the general rule on non-approved substances (S0) can still apply. 5-Amino-1MQ is banned by WADA, by name or as part of a named class.