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Longevity & Skin
Tetrapeptide proposed to support telomerase and circadian rhythm.
Longevity & Skin
A mitochondria-derived peptide studied for metabolism and exercise capacity.
Epithalon is not FDA-approved and rated 2/5 for evidence; MOTS-c is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are banned in sport by WADA. Both are used for longevity & skin goals.
| Compare | Epithalon Tetrapeptide proposed to support telomerase and circadian rhythm. | MOTS-c A mitochondria-derived peptide studied for metabolism and exercise capacity. |
|---|---|---|
| Category | Longevity & Skin | Longevity & Skin |
| Evidence | 2/5Mostly Russian research groups; independent replication lacking. | 2/5Mostly mouse studies; very early human work (levels rise with exercise). |
| FDA status | Not FDA-approved | Not FDA-approved |
| WADA (sport) | Banned | Banned |
| Also known as | Epitalon, Epithalone, AEDG | Mitochondrial ORF of the 12S rRNA-c |
| How it works | Proposed to activate telomerase and boost melatonin production from the pineal gland. Mechanisms not confirmed by independent Western research. | Activates AMPK and shifts cellular metabolism, mimicking some exercise effects. |
| Half-life | Short | Short |
| Commonly reported doses |
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| Route | Subcutaneous | Subcutaneous |
| Good once mixed | ~30 days in the fridge | ~28 days in the fridge |
| Top side effects |
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| Lowest research-listing price per mg | $1.80 (10 mg vial, 40% off) | $2.02 (40 mg vial, 40% off) |
| Latest lab purity | 99.26% (lot EPI0002) | 99.81% (lot MTC0003) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Epithalon is not FDA-approved and rated 2/5 for evidence; MOTS-c is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are banned in sport by WADA. Both are used for longevity & skin goals.
Epithalon: Not FDA-approved. MOTS-c: Not FDA-approved. Regulations change, so confirm with the FDA.
Epithalon is rated 2 out of 5: Mostly Russian research groups; independent replication lacking. MOTS-c is rated 2 out of 5: Mostly mouse studies; very early human work (levels rise with exercise). The scale is explained on our methodology page.
Epithalon is banned by WADA, by name or as part of a named class. MOTS-c is banned by WADA, by name or as part of a named class.