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Growth Hormone Axis
The classic GH-stimulating pair in one vial.
Growth Hormone Axis
The first 29 amino acids of natural GHRH. FDA-approved as Geref until it was withdrawn in 2008.
CJC-1295 (no DAC) + Ipamorelin is not FDA-approved and rated 3/5 for evidence; Sermorelin is not FDA-approved and rated 4/5. Sermorelin has more human evidence behind it. Both are banned in sport by WADA. Both are used for growth hormone axis goals.
| Compare | CJC-1295 (no DAC) + Ipamorelin The classic GH-stimulating pair in one vial. | Sermorelin The first 29 amino acids of natural GHRH. FDA-approved as Geref until it was withdrawn in 2008. |
|---|---|---|
| Category | Growth Hormone Axis | Growth Hormone Axis |
| Evidence | 3/5Each component studied in humans for GH release; the combined long-term outcomes data is thin. | 4/5Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older. |
| FDA status | Not FDA-approved | Formerly FDA-approved (Geref) — discontinued 2008 |
| WADA (sport) | Banned | Banned |
| Also known as | Modified GRF 1-29 + Ipamorelin, CJC/Ipa blend | Geref, GRF 1-29 NH2, Sermorelin acetate |
| How it works | Two receptors, one pulse: GHRH-receptor stimulation (CJC-1295) plus ghrelin-receptor stimulation (ipamorelin) produces a larger-than-either GH release. Short half-life keeps the pulsatile pattern. | Binds the GHRH receptor on the pituitary, triggering a short pulse of growth hormone and a rise in IGF-1. The body's normal feedback (somatostatin) still applies, so levels stay within a more natural range than injected GH. |
| Half-life | CJC no-DAC ≈ 30 min; ipamorelin ≈ 2 h | About 10–20 minutes; the GH pulse lasts a few hours |
| Commonly reported doses |
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| Route | Subcutaneous | Subcutaneous |
| Good once mixed | ~21 days in the fridge | ~21 days in the fridge |
| Top side effects |
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| Lowest research-listing price per mg | $3.60 (10 mg vial, 40% off) | $3.60 (10 mg vial, 40% off) |
| Latest lab purity | 99.12% (lot CIP0003) | 99.41% (lot SER0002) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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CJC-1295 (no DAC) + Ipamorelin is not FDA-approved and rated 3/5 for evidence; Sermorelin is not FDA-approved and rated 4/5. Sermorelin has more human evidence behind it. Both are banned in sport by WADA. Both are used for growth hormone axis goals.
CJC-1295 (no DAC) + Ipamorelin: Not FDA-approved. Sermorelin: Formerly FDA-approved (Geref) — discontinued 2008. Regulations change, so confirm with the FDA.
CJC-1295 (no DAC) + Ipamorelin is rated 3 out of 5: Each component studied in humans for GH release; the combined long-term outcomes data is thin. Sermorelin is rated 4 out of 5: Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older. The scale is explained on our methodology page.
CJC-1295 (no DAC) + Ipamorelin is banned by WADA, by name or as part of a named class. Sermorelin is banned by WADA, by name or as part of a named class.