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Longevity & Skin
A mitochondria-derived peptide studied for metabolism and exercise capacity.
Metabolic & Weight
A small-molecule NNMT blocker with mouse data only — not actually a peptide.
MOTS-c is not FDA-approved and rated 2/5 for evidence; 5-Amino-1MQ is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are banned in sport by WADA. MOTS-c is listed under Longevity & Skin; 5-Amino-1MQ under Metabolic & Weight.
| Compare | MOTS-c A mitochondria-derived peptide studied for metabolism and exercise capacity. | 5-Amino-1MQ A small-molecule NNMT blocker with mouse data only — not actually a peptide. |
|---|---|---|
| Category | Longevity & Skin | Metabolic & Weight |
| Evidence | 2/5Mostly mouse studies; very early human work (levels rise with exercise). | 2/5Cell studies and a small number of mouse studies; no published human trials. |
| FDA status | Not FDA-approved | Not FDA-approved |
| WADA (sport) | Banned | Banned |
| Also known as | Mitochondrial ORF of the 12S rRNA-c | 5-amino-1-methylquinolinium, NNMT inhibitor |
| How it works | Activates AMPK and shifts cellular metabolism, mimicking some exercise effects. | Inhibits nicotinamide N-methyltransferase (NNMT). Less NNMT activity is thought to preserve NAD+ and SAM (a methyl donor) inside fat cells, nudging them to burn more energy and store less fat. This is based on cell and mouse work. |
| Half-life | Short | Not established in humans |
| Commonly reported doses |
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| Route | Subcutaneous | Subcutaneous |
| Good once mixed | ~28 days in the fridge | ~28 days in the fridge |
| Top side effects |
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| Lowest research-listing price per mg | $2.02 (40 mg vial, 40% off) | $0.60 (50 mg vial, 40% off) |
| Latest lab purity | 99.81% (lot MTC0003) | 99.97% (lot AMQ0002) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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MOTS-c is not FDA-approved and rated 2/5 for evidence; 5-Amino-1MQ is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are banned in sport by WADA. MOTS-c is listed under Longevity & Skin; 5-Amino-1MQ under Metabolic & Weight.
MOTS-c: Not FDA-approved. 5-Amino-1MQ: Not FDA-approved. Regulations change, so confirm with the FDA.
MOTS-c is rated 2 out of 5: Mostly mouse studies; very early human work (levels rise with exercise). 5-Amino-1MQ is rated 2 out of 5: Cell studies and a small number of mouse studies; no published human trials. The scale is explained on our methodology page.
MOTS-c is banned by WADA, by name or as part of a named class. 5-Amino-1MQ is banned by WADA, by name or as part of a named class.