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Cognitive & Mood
Sleep-promoting peptide first isolated from rabbit brain in the 1970s.
Cognitive & Mood
A three-amino-acid Khavinson 'bioregulator' aimed at the brain.
DSIP is not FDA-approved and rated 2/5 for evidence; Pinealon is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are banned in sport by WADA. Both are used for cognitive & mood goals.
| Compare | DSIP Sleep-promoting peptide first isolated from rabbit brain in the 1970s. | Pinealon A three-amino-acid Khavinson 'bioregulator' aimed at the brain. |
|---|---|---|
| Category | Cognitive & Mood | Cognitive & Mood |
| Evidence | 2/5Mixed small human trials from the 1980s–90s; no modern RCTs. | 2/5Cell and animal studies from the developing group; one small uncontrolled human cohort. No placebo-controlled trials. |
| FDA status | Not FDA-approved | Not FDA-approved |
| WADA (sport) | Banned | Banned |
| Also known as | Delta Sleep-Inducing Peptide | EDR, Glu-Asp-Arg |
| How it works | Poorly understood; modulates stress hormones and sleep architecture. Short half-life. | Proposed to enter cells and interact with DNA to influence gene activity, and to reduce oxidative stress in neurons. These ideas come mainly from the developers' lab and are not independently confirmed. |
| Half-life | About 7–8 minutes | Not well characterized; likely short |
| Commonly reported doses |
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| Route | Subcutaneous | Subcutaneous |
| Good once mixed | ~14 days in the fridge | ~30 days in the fridge |
| Top side effects |
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| Lowest research-listing price per mg | $3.60 (5 mg vial, 40% off) | $3.00 (10 mg vial, 40% off) |
| Latest lab purity | 99.45% (lot DSP0001) | 99.90% (lot PIN0002) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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DSIP is not FDA-approved and rated 2/5 for evidence; Pinealon is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are banned in sport by WADA. Both are used for cognitive & mood goals.
DSIP: Not FDA-approved. Pinealon: Not FDA-approved. Regulations change, so confirm with the FDA.
DSIP is rated 2 out of 5: Mixed small human trials from the 1980s–90s; no modern RCTs. Pinealon is rated 2 out of 5: Cell and animal studies from the developing group; one small uncontrolled human cohort. No placebo-controlled trials. The scale is explained on our methodology page.
DSIP is banned by WADA, by name or as part of a named class. Pinealon is banned by WADA, by name or as part of a named class.