Epithalon vs NAD+
Epithalon is not FDA-approved and rated 2/5 for evidence; NAD+ is not FDA-approved and rated 2/5. They have a similar amount of human evidence. Both are used for longevity & skin goals.
| Compare |  EpithalonTetrapeptide proposed to support telomerase and circadian rhythm. |  NAD+A core cellular coenzyme that declines with age — popular for 'energy', thin on proof. |
|---|---|---|
| Category | Longevity & Skin | Longevity & Skin |
| Evidence | 2/5Mostly Russian research groups; independent replication lacking. | 2/5Strong biology and mouse aging studies; human trials mostly test oral precursors (NR, NMN). Direct NAD+ injection/infusion has only small pharmacokinetic studies. |
| FDA status | Not FDA-approved | Not FDA-approved as a drug |
| WADA (sport) | Not prohibited | Not prohibited |
| Also known as | Epitalon, Epithalone, AEDG | Nicotinamide adenine dinucleotide, β-NAD, Coenzyme I |
| How it works | Proposed to activate telomerase and boost melatonin production from the pineal gland. Mechanisms not confirmed by independent Western research. | Shuttles electrons in energy metabolism and is consumed by sirtuins, PARPs (DNA repair) and CD38. Injected NAD+ is likely broken down to smaller precursors outside cells before being taken up, so how much reaches cells intact is unclear. |
| Half-life | Short | Short in blood (minutes to hours); quickly broken down to precursors |
| Commonly reported doses |
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| Route | Subcutaneous | Subcutaneous |
| Good once mixed | ~30 days in the fridge | ~14 days in the fridge |
| Top side effects |
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| Lowest price per mg | $1.80 (10 mg vial, 40% off) | $0.08 (500 mg vial, 40% off) |
| Latest lab purity | 99.26% (lot EPI0002) | 99.18% (lot NAD0002) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.