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Metabolic & Weight
The GLP-1 drug that started the modern weight-loss era: Ozempic and Wegovy.
Metabolic & Weight
A triple monoamine reuptake inhibitor under study for obesity.
Semaglutide is FDA-approved and rated 5/5 for evidence; Tesofensine is not FDA-approved and rated 3/5. Semaglutide has more human evidence behind it. Tesofensine is banned in sport by WADA; Semaglutide is not. Both are used for metabolic & weight goals.
| Compare | Semaglutide The GLP-1 drug that started the modern weight-loss era: Ozempic and Wegovy. | Tesofensine A triple monoamine reuptake inhibitor under study for obesity. |
|---|---|---|
| Category | Metabolic & Weight | Metabolic & Weight |
| Evidence | 5/5FDA-approved with large RCT programs (SUSTAIN, STEP, SELECT). SELECT showed a 20% reduction in major cardiovascular events in people with heart disease and overweight. | 3/5Phase‑2 randomized controlled trials in hypothalamic obesity and Prader‑Willi syndrome; animal studies show metabolic effects. |
| FDA status | FDA-approved (Ozempic 2017, Wegovy 2021) | Not FDA-approved |
| WADA (sport) | Not on the Prohibited List | Banned |
| Also known as | Ozempic, Wegovy, Rybelsus, NN9535, AMP-1 (SM) | – |
| How it works | A modified version of the natural hormone GLP-1 with a fatty-acid side chain that binds albumin, stretching its half-life to about a week. It lowers appetite through the brain, slows stomach emptying, and increases insulin release when blood sugar is high. | Blocks reuptake of noradrenaline, dopamine and serotonin, leading to increased signaling that suppresses appetite and boosts metabolism. |
| Half-life | About 7 days (once-weekly dosing) | Unknown |
| Commonly reported doses |
| |
| Route | Subcutaneous (abdomen, thigh, upper arm) | – |
| Good once mixed | ~28 days in the fridge | No published dose yet |
| Top side effects |
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| Lowest research-listing price per mg | $3.00 (10 mg vial, 40% off) | – |
| Latest lab purity | 99.90% (lot SEM0002) | – |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Semaglutide is FDA-approved and rated 5/5 for evidence; Tesofensine is not FDA-approved and rated 3/5. Semaglutide has more human evidence behind it. Tesofensine is banned in sport by WADA; Semaglutide is not. Both are used for metabolic & weight goals.
Semaglutide: FDA-approved (Ozempic 2017, Wegovy 2021). Tesofensine: Not FDA-approved. Regulations change, so confirm with the FDA.
Semaglutide is rated 5 out of 5: FDA-approved with large RCT programs (SUSTAIN, STEP, SELECT). SELECT showed a 20% reduction in major cardiovascular events in people with heart disease and overweight. Tesofensine is rated 3 out of 5: Phase‑2 randomized controlled trials in hypothalamic obesity and Prader‑Willi syndrome; animal studies show metabolic effects. The scale is explained on our methodology page.
Semaglutide is not named on the WADA list, though the general rule on non-approved substances (S0) can still apply. Tesofensine is banned by WADA, by name or as part of a named class.