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Metabolic & Weight
The dual GIP/GLP-1 agonist behind Mounjaro and Zepbound.
Metabolic & Weight
A small-molecule NNMT blocker with mouse data only — not actually a peptide.
Tirzepatide is FDA-approved and rated 5/5 for evidence; 5-Amino-1MQ is not FDA-approved and rated 2/5. Tirzepatide has more human evidence behind it. 5-Amino-1MQ is banned in sport by WADA; Tirzepatide is not. Both are used for metabolic & weight goals.
| Compare | Tirzepatide The dual GIP/GLP-1 agonist behind Mounjaro and Zepbound. | 5-Amino-1MQ A small-molecule NNMT blocker with mouse data only — not actually a peptide. |
|---|---|---|
| Category | Metabolic & Weight | Metabolic & Weight |
| Evidence | 5/5FDA-approved on the basis of large phase 3 programs (SURPASS for diabetes, SURMOUNT for obesity, SURMOUNT-OSA for sleep apnea). | 2/5Cell studies and a small number of mouse studies; no published human trials. |
| FDA status | FDA-approved (Mounjaro 2022, Zepbound 2023) | Not FDA-approved |
| WADA (sport) | Not on the Prohibited List | Banned |
| Also known as | Mounjaro, Zepbound, LY3298176, AMP-2 (TR) | 5-amino-1-methylquinolinium, NNMT inhibitor |
| How it works | A 39-amino-acid peptide with a C20 fatty diacid at lysine-20 that binds albumin, so it lasts about 5 days. GLP-1 and GIP receptor activation lowers appetite, slows stomach emptying, and boosts insulin release when blood sugar is high. | Inhibits nicotinamide N-methyltransferase (NNMT). Less NNMT activity is thought to preserve NAD+ and SAM (a methyl donor) inside fat cells, nudging them to burn more energy and store less fat. This is based on cell and mouse work. |
| Half-life | About 5 days (once-weekly dosing) | Not established in humans |
| Commonly reported doses |
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| Route | Subcutaneous (abdomen, thigh, upper arm) | Subcutaneous |
| Good once mixed | ~28 days in the fridge | ~28 days in the fridge |
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| Lowest research-listing price per mg | $1.10 (60 mg vial, 40% off) | $0.60 (50 mg vial, 40% off) |
| Latest lab purity | 99.90% (lot TRZ0003) | 99.97% (lot AMQ0002) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Tirzepatide is FDA-approved and rated 5/5 for evidence; 5-Amino-1MQ is not FDA-approved and rated 2/5. Tirzepatide has more human evidence behind it. 5-Amino-1MQ is banned in sport by WADA; Tirzepatide is not. Both are used for metabolic & weight goals.
Tirzepatide: FDA-approved (Mounjaro 2022, Zepbound 2023). 5-Amino-1MQ: Not FDA-approved. Regulations change, so confirm with the FDA.
Tirzepatide is rated 5 out of 5: FDA-approved on the basis of large phase 3 programs (SURPASS for diabetes, SURMOUNT for obesity, SURMOUNT-OSA for sleep apnea). 5-Amino-1MQ is rated 2 out of 5: Cell studies and a small number of mouse studies; no published human trials. The scale is explained on our methodology page.
Tirzepatide is not named on the WADA list, though the general rule on non-approved substances (S0) can still apply. 5-Amino-1MQ is banned by WADA, by name or as part of a named class.