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Cognitive & Mood
Russian-developed nootropic peptide, approved there for stroke recovery.
Cognitive & Mood
A modified Semax sold only as a ready-made nasal spray. Evidence is borrowed from Semax.
Semax is not FDA-approved and rated 3/5 for evidence; Adamax is not FDA-approved and rated 1/5. Semax has more human evidence behind it. Adamax is banned in sport by WADA; Semax is not. Both are used for cognitive & mood goals.
| Compare | Semax Russian-developed nootropic peptide, approved there for stroke recovery. | Adamax A modified Semax sold only as a ready-made nasal spray. Evidence is borrowed from Semax. |
|---|---|---|
| Category | Cognitive & Mood | Cognitive & Mood |
| Evidence | 3/5Clinical use in Russia with small trials; little Western randomized data. | 1/5No published research on Adamax. Effects are inferred from Semax, which has small Russian clinical studies. |
| FDA status | Not FDA-approved | Not FDA-approved |
| WADA (sport) | Not on the Prohibited List | Banned |
| Also known as | ACTH(4-7)-PGP | Adamax Research Mist, N-acetyl Semax analog |
| How it works | Increases BDNF and NGF expression, modulates dopamine and serotonin signaling, and shows neuroprotective effects in ischemia models. | Assumed to work like Semax: raising BDNF and modulating dopamine and serotonin signaling. Whether the modifications change potency or duration has not been tested. |
| Half-life | Short (minutes); effects last hours | Unknown; marketed as longer-acting than Semax, unproven |
| Commonly reported doses |
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| Route | Intranasal or subcutaneous | Intranasal |
| Good once mixed | ~21 days in the fridge | Ready-made spray |
| Top side effects |
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| Lowest research-listing price per mg | $1.80 (10 mg vial, 40% off) | $3.60 (15 mg vial, 40% off) |
| Latest lab purity | 99.93% (lot SMX0002) | 99.10% (lot SADM0001) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Semax is not FDA-approved and rated 3/5 for evidence; Adamax is not FDA-approved and rated 1/5. Semax has more human evidence behind it. Adamax is banned in sport by WADA; Semax is not. Both are used for cognitive & mood goals.
Semax: Not FDA-approved. Adamax: Not FDA-approved. Regulations change, so confirm with the FDA.
Semax is rated 3 out of 5: Clinical use in Russia with small trials; little Western randomized data. Adamax is rated 1 out of 5: No published research on Adamax. Effects are inferred from Semax, which has small Russian clinical studies. The scale is explained on our methodology page.
Semax is not named on the WADA list, though the general rule on non-approved substances (S0) can still apply. Adamax is banned by WADA, by name or as part of a named class.