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Sexual Health
The master switch for reproductive hormones — studied in real human trials.
Women's Health
A non‑hormonal peptide aimed at disease‑modifying treatment for endometriosis.
Kisspeptin-10 is not FDA-approved and rated 3/5 for evidence; ENDO-205 is not FDA-approved and rated 2/5. Kisspeptin-10 has more human evidence behind it. Kisspeptin-10 is banned in sport by WADA; ENDO-205 is not. Kisspeptin-10 is listed under Sexual Health; ENDO-205 under Women's Health.
| Compare | Kisspeptin-10 The master switch for reproductive hormones — studied in real human trials. | ENDO-205 A non‑hormonal peptide aimed at disease‑modifying treatment for endometriosis. |
|---|---|---|
| Category | Sexual Health | Women's Health |
| Evidence | 3/5Many small human physiology studies and early-phase clinical trials (IVF egg maturation, low sexual desire). No large Phase 3 trials and no approval. | 2/5Preclinical (animal) studies have shown lesion reduction; no human efficacy data yet. |
| FDA status | Not FDA-approved | IND cleared; not FDA‑approved |
| WADA (sport) | Banned | Not on the Prohibited List |
| Also known as | Kisspeptin, KP-10, Metastin 45-54 | – |
| How it works | Activates the KISS1 receptor on GnRH neurons in the hypothalamus, triggering GnRH release. That leads the pituitary to release LH and FSH, which drive testosterone and estrogen production. Brain-imaging studies also suggest it enhances processing of sexual and romantic cues. | The peptide is designed to bind a downstream component of a pathway that drives endometriosis lesion migration and invasion, and is reported to be absorbed primarily in endometriosis tissue. |
| Half-life | Very short — a few minutes in blood (kisspeptin-10) | Unknown |
| Commonly reported doses |
| |
| Route | Subcutaneous | – |
| Good once mixed | ~28 days in the fridge | No published dose yet |
| Top side effects |
| |
| Lowest research-listing price per mg | $3.00 (10 mg vial, 40% off) | – |
| Latest lab purity | 99.89% (lot KSI0002) | – |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.
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Kisspeptin-10 is not FDA-approved and rated 3/5 for evidence; ENDO-205 is not FDA-approved and rated 2/5. Kisspeptin-10 has more human evidence behind it. Kisspeptin-10 is banned in sport by WADA; ENDO-205 is not. Kisspeptin-10 is listed under Sexual Health; ENDO-205 under Women's Health.
Kisspeptin-10: Not FDA-approved. ENDO-205: IND cleared; not FDA‑approved. Regulations change, so confirm with the FDA.
Kisspeptin-10 is rated 3 out of 5: Many small human physiology studies and early-phase clinical trials (IVF egg maturation, low sexual desire). No large Phase 3 trials and no approval. ENDO-205 is rated 2 out of 5: Preclinical (animal) studies have shown lesion reduction; no human efficacy data yet. The scale is explained on our methodology page.
Kisspeptin-10 is banned by WADA, by name or as part of a named class. ENDO-205 is not named on the WADA list, though the general rule on non-approved substances (S0) can still apply.