Tesamorelin vs Sermorelin
Tesamorelin is FDA-approved and rated 5/5 for evidence; Sermorelin is not FDA-approved and rated 4/5. Tesamorelin has more human evidence behind it. Both are banned in sport by WADA. Both are used for growth hormone axis goals.
| Compare |  TesamorelinThe only FDA-approved GHRH analog — proven against belly fat. |  SermorelinThe first 29 amino acids of natural GHRH — once an FDA-approved drug. |
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| Category | Growth Hormone Axis | Growth Hormone Axis |
| Evidence | 5/5Phase 3 RCTs in HIV lipodystrophy led to FDA approval; off-label populations less studied. | 4/5Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older. |
| FDA status | FDA-approved (Egrifta, 2010) | Formerly FDA-approved (Geref) — discontinued 2008 |
| WADA (sport) | Banned | Banned |
| Also known as | Egrifta, TH9507 | Geref, GRF 1-29 NH2, Sermorelin acetate |
| How it works | Stimulates pituitary GH release through the GHRH receptor, raising IGF-1 and reducing visceral adipose tissue while preserving the natural pulse pattern. | Binds the GHRH receptor on the pituitary, triggering a short pulse of growth hormone and a rise in IGF-1. The body's normal feedback (somatostatin) still applies, so levels stay within a more natural range than injected GH. |
| Half-life | About 25–40 minutes | About 10–20 minutes; the GH pulse lasts a few hours |
| Commonly reported doses |
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| Route | Subcutaneous, abdomen | Subcutaneous |
| Good once mixed | ~14 days in the fridge | ~21 days in the fridge |
| Top side effects |
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| Lowest price per mg | $4.20 (10 mg vial, 40% off) | $3.60 (10 mg vial, 40% off) |
| Latest lab purity | 99.61% (lot TES0003) | 99.15% (lot SER0001) |
Want a third? Add another peptide. Doses are commonly reported ranges, not recommendations.