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Compare	Semax Russian-developed nootropic peptide, approved there for stroke recovery.	Selank Calming nootropic peptide built from the immune peptide tuftsin.
Category	Cognitive & Mood	Cognitive & Mood
Evidence	3/5Clinical use in Russia with small trials; little Western randomized data.	3/5Small Russian clinical trials in generalized anxiety; limited Western data.
FDA status	Not FDA-approved	Not FDA-approved
WADA (sport)	Not prohibited	Not prohibited
Also known as	ACTH(4-7)-PGP	TP-7 analog, Tuftsin analog
How it works	Increases BDNF and NGF expression, modulates dopamine and serotonin signaling, and shows neuroprotective effects in ischemia models.	Modulates GABA signaling, enkephalin breakdown, and serotonin/BDNF expression; also influences cytokine balance.
Half-life	Short (minutes); effects last hours	Short; effects last hours
Commonly reported doses	Nasal / injected (community): 300 mcg, 1–2× daily, morning/midday	Standard: 300 mcg, 1–2× daily
Route	Intranasal or subcutaneous	Intranasal or subcutaneous
Good once mixed	~21 days in the fridge	~21 days in the fridge
Top side effects	Irritability or overstimulation Nasal irritation Headache	Mild drowsiness Nasal dryness Headache
Lowest price per mg	$1.80 (10 mg vial, 40% off)	$1.80 (10 mg vial, 40% off)
Latest lab purity	99.93% (lot SMX0002)	99.49% (lot SLK0001)
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