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Compare	Semaglutide The GLP-1 drug that started the modern weight-loss era: Ozempic and Wegovy.	Cagrilintide A long-acting amylin analog — the 'Cagri' half of CagriSema.
Category	Metabolic & Weight	Metabolic & Weight
Evidence	5/5FDA-approved with large RCT programs (SUSTAIN, STEP, SELECT). SELECT showed a 20% reduction in major cardiovascular events in people with heart disease and overweight.	4/5Phase 2 RCT of cagrilintide alone and large phase 3 RCTs (REDEFINE) with a cagrilintide-only arm. Not approved as a standalone drug.
FDA status	FDA-approved (Ozempic 2017, Wegovy 2021)	Not FDA-approved
WADA (sport)	Not prohibited	Not prohibited
Also known as	Ozempic, Wegovy, Rybelsus, NN9535, AMP-1 (SM)	NN9838, AM833, Cagri
How it works	A modified version of the natural hormone GLP-1 with a fatty-acid side chain that binds albumin, stretching its half-life to about a week. It lowers appetite through the brain, slows stomach emptying, and increases insulin release when blood sugar is high.	A 37-amino-acid modified amylin analog with a C18 fatty diacid for a long half-life. It activates amylin and calcitonin receptors in the brain, increasing fullness and slowing stomach emptying — a different pathway from GLP-1, which is why the two are combined.
Half-life	About 7 days (once-weekly dosing)	About 7–8 days (once-weekly dosing)
Commonly reported doses	Wegovy label start: 250 mcg, once weekly Ozempic step 2: 500 mcg, once weekly Wegovy maintenance: 2.4 mg, once weekly	Trial-style start: 250 mcg, once weekly Phase 3 target dose: 2.4 mg, once weekly
Route	Subcutaneous (abdomen, thigh, upper arm)	Subcutaneous
Good once mixed	~28 days in the fridge	~28 days in the fridge
Top side effects	Nausea, vomiting, diarrhea, constipation (most common, worst during dose increases) Belly pain, bloating, burping Fatigue, headache	Nausea, vomiting, constipation, diarrhea Reduced appetite Fatigue
Lowest price per mg	$3.00 (10 mg vial, 40% off)	$4.20 (10 mg vial, 40% off)
Latest lab purity	99.17% (lot SEM0001)	99.84% (lot CAG0002)
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