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ComparePT-141

Works through the brain, not blood flow — and it's FDA-approved for women.

Kisspeptin-10

The master switch for reproductive hormones — studied in real human trials.

CategorySexual HealthSexual Health
Evidence 4/5Phase 3 RCTs in women (RECONNECT) led to FDA approval; men's data is smaller. 3/5Many small human physiology studies and early-phase clinical trials (IVF egg maturation, low sexual desire). No large Phase 3 trials and no approval.
FDA statusFDA-approved (Vyleesi, 2019) for premenopausal women with HSDDNot FDA-approved
WADA (sport)Not prohibitedBanned
Also known asBremelanotide, VyleesiKisspeptin, KP-10, Metastin 45-54
How it worksMelanocortin-4 receptor agonist in the hypothalamus; acts on desire pathways rather than vascular function.Activates the KISS1 receptor on GnRH neurons in the hypothalamus, triggering GnRH release. That leads the pituitary to release LH and FSH, which drive testosterone and estrogen production. Brain-imaging studies also suggest it enhances processing of sexual and romantic cues.
Half-lifeAbout 2–3 hoursVery short — a few minutes in blood (kisspeptin-10)
Commonly reported doses
  • FDA label (Vyleesi): 1.75 mg, as needed, ≥45 min before activity; max 1 dose per 24 h, 8 per month
  • Community (men & women): 1 mg, as needed, 45–90 min before
  • Community: 100 mcg, once daily or a few times per week
RouteSubcutaneous (abdomen/thigh)Subcutaneous
Good once mixed~28 days in the fridge~28 days in the fridge
Top side effects
  • Nausea (very common, ~40%)
  • Flushing
  • Headache
  • Generally well tolerated in short studies
  • Mild injection-site reaction
  • Flushing or headache (occasional)
Lowest price per mg$1.80 (10 mg vial, 40% off)$3.00 (10 mg vial, 40% off)
Latest lab purity99.91% (lot PT0002)99.24% (lot KSI0001)
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