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CompareIpamorelin

A selective growth-hormone secretagogue with a clean side-effect profile.

Sermorelin

The first 29 amino acids of natural GHRH — once an FDA-approved drug.

CategoryGrowth Hormone AxisGrowth Hormone Axis
Evidence 3/5Phase 2 human trials for postoperative ileus; GH-release effects are well documented in humans. 4/5Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older.
FDA statusNot FDA-approvedFormerly FDA-approved (Geref) — discontinued 2008
WADA (sport)BannedBanned
Also known asNNC 26-0161Geref, GRF 1-29 NH2, Sermorelin acetate
How it worksGhrelin-receptor (GHS-R1a) agonist producing a short, pulsatile GH release. Often paired with a GHRH analog (CJC-1295, sermorelin) for a stronger combined pulse.Binds the GHRH receptor on the pituitary, triggering a short pulse of growth hormone and a rise in IGF-1. The body's normal feedback (somatostatin) still applies, so levels stay within a more natural range than injected GH.
Half-lifeAbout 2 hoursAbout 10–20 minutes; the GH pulse lasts a few hours
Commonly reported doses
  • Standard: 200 mcg, 1–3× daily (often bedtime)
  • Higher: 300 mcg, 2× daily
  • Community: 300 mcg, once daily at bedtime
RouteSubcutaneousSubcutaneous
Good once mixed~30 days in the fridge~21 days in the fridge
Top side effects
  • Head rush / flushing right after injection
  • Mild water retention
  • Increased hunger
  • Facial flushing right after injection
  • Injection-site pain, redness or swelling
  • Headache
Lowest price per mg$3.00 (10 mg vial, 40% off)$3.60 (10 mg vial, 40% off)
Latest lab purity99.79% (lot IPA0002)99.15% (lot SER0001)

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