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CompareGHK-Cu

A natural copper-binding tripeptide with decades of skin research.

AHK-Cu

GHK-Cu's lesser-known cousin, researched mainly for hair follicles.

CategoryLongevity & SkinLongevity & Skin
Evidence 3/5Several small human topical/cosmetic studies; injection data is mainly preclinical. 1/5Mainly in-vitro and ex-vivo hair follicle studies. Little to no controlled human data.
FDA statusCosmetic ingredient; injectable not approvedNot a drug; used as a cosmetic ingredient
WADA (sport)Not prohibitedNot prohibited
Also known asCopper tripeptide-1, Glycyl-L-histidyl-L-lysine copperCopper tripeptide-3, Alanyl-histidyl-lysine copper
How it worksDelivers copper to tissue, stimulates collagen and glycosaminoglycan synthesis, supports wound remodeling, and appears to reset expression of many genes toward a younger profile (gene-expression studies).In lab studies it stimulated growth of isolated human hair follicles and dermal papilla cells (the cells that control hair growth) and reduced cell death in those cells. Like GHK-Cu, it delivers copper and may encourage collagen production in skin cells.
Half-lifeShort (minutes–hours); effects driven by gene/repair signalingNot characterized in humans
Commonly reported doses
  • Systemic (community): 1 mg, once daily
  • Topical serum: –, once or twice daily
  • Topical scalp serum: –, once daily
  • Community (injectable): 1 mg, once daily
RouteSubcutaneousTopical
Good once mixed~30 days in the fridge~30 days in the fridge
Top side effects
  • Stinging at injection site
  • Skin redness
  • Headache or dizziness
  • Stinging or redness at injection or application site
  • Scalp irritation
  • Possible temporary shedding early on (reported by users)
Lowest price per mg$0.35 (100 mg vial, 40% off)$0.36 (100 mg vial, 40% off)
Latest lab purity99.94% (lot GHK0003)99.78% (lot AHK0001)
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