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CompareAOD-9604

A growth-hormone fragment developed for obesity — it failed its key trial.

5-Amino-1MQ

A small-molecule NNMT blocker with mouse data only — not actually a peptide.

CategoryMetabolic & WeightMetabolic & Weight
Evidence 3/5Human trials exist and showed it was well tolerated, but the largest (phase 2b, 536 people) missed its weight-loss endpoint. Positive findings are mostly from animals. 2/5Cell studies and a small number of mouse studies; no published human trials.
FDA statusNot FDA-approvedNot FDA-approved
WADA (sport)BannedNot prohibited
Also known asAnti-Obesity Drug 9604, Tyr-hGH(177-191), hGH fragment 176-191 (modified)5-amino-1-methylquinolinium, NNMT inhibitor
How it worksProposed to stimulate fat breakdown (lipolysis) and block fat storage in fat cells, mimicking a region of GH. It does not raise IGF-1 the way full GH does. Mechanism in humans is not well established.Inhibits nicotinamide N-methyltransferase (NNMT). Less NNMT activity is thought to preserve NAD+ and SAM (a methyl donor) inside fat cells, nudging them to burn more energy and store less fat. This is based on cell and mouse work.
Half-lifeShort (minutes to under an hour); not well characterizedNot established in humans
Commonly reported doses
  • Community-reported: 300 mcg, once daily, usually fasted in the morning
  • Community-reported higher: 500 mcg, once daily
  • Community-reported (vial): 5 mg, once daily
  • Community-reported (oral capsule): 50 mg, 1–3× daily
RouteSubcutaneous, abdomenSubcutaneous
Good once mixed~28 days in the fridge~28 days in the fridge
Top side effects
  • Injection-site redness or irritation
  • Headache
  • Mild nausea
  • Injection-site stinging
  • Nausea or stomach upset (oral)
  • Headache
Lowest price per mg$6.00 (5 mg vial, 40% off)$0.60 (50 mg vial, 40% off)
Latest lab purity99.68% (lot AOD0002)99.97% (lot AMQ0002)

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