Peptides for focus, mood and sleep
8 peptides used for focus, mood and sleep, ranked by how much human research backs each one. Status, lab purity and mixing math for every one. Educational, not medical advice.
Ranked by evidence
Selank
Calming nootropic peptide built from the immune peptide tuftsin.
Small Russian clinical trials in generalized anxiety; limited Western data.
Semax
Russian-developed nootropic peptide, approved there for stroke recovery.
Clinical use in Russia with small trials; little Western randomized data.
Dihexa
A small angiotensin-derived compound with striking rat memory data and no human trials.
Animal and cell data from one main research group. No published human trials. A related HGF-boosting drug from the same lineage (fosgonimeton) missed its main goal in a Phase 2/3 Alzheimer's trial.
DSIP
Sleep-promoting peptide first isolated from rabbit brain in the 1970s.
Mixed small human trials from the 1980s–90s; no modern RCTs.
Pinealon
A three-amino-acid Khavinson 'bioregulator' aimed at the brain.
Cell and animal studies from the developing group; one small uncontrolled human cohort. No placebo-controlled trials.
Selank + Semax + Pinealon spray
Three nootropic peptides in one ready-made nasal spray.
Semax and Selank have small Russian clinical trials; Pinealon is mostly preclinical. The blend itself has no data.
Adalank
A capped Selank sold only as a ready-made nasal spray. Evidence is borrowed from Selank.
No published research on Adalank. Effects are inferred from Selank's small Russian clinical trials.
Adamax
A modified Semax sold only as a ready-made nasal spray. Evidence is borrowed from Semax.
No published research on Adamax. Effects are inferred from Semax, which has small Russian clinical studies.
Ranked by human evidence (how we rate it), then FDA approval. Higher isn’t a recommendation to use anything.
Compare them head to head
- Semax vs Selank
- Selank vs DSIP
- Semax vs Dihexa
- Adamax vs Adalank
- Semax vs Adamax
- Selank vs Adalank
- Selank + Semax + Pinealon spray vs Semax
- Semax vs Pinealon
- Selank vs Pinealon
- DSIP vs Pinealon
- Dihexa vs Adamax
- Pinealon vs Dihexa
- Selank vs Selank + Semax + Pinealon spray
- Semax vs Adalank
- Selank vs Adamax
- Dihexa vs Adalank
Common questions
What is the best-researched peptide for focus, mood and sleep?
Selank, rated 3/5 for human evidence: Small Russian clinical trials in generalized anxiety; limited Western data.
Are any peptides for focus, mood and sleep FDA approved?
No. None of the 8 peptides here is FDA approved for this use; most are sold as research chemicals.
Which are banned in sport?
WADA bans Dihexa, DSIP, Pinealon, Selank + Semax + Pinealon spray, Adalank, Adamax.
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