18+ and educational only: not medical advice.
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Growth hormone peptides

5 peptides used for growth hormone release, ranked by how much human research backs each one. Status, lab purity and mixing math for every one. Educational, not medical advice.

Ranked by evidence

  1. Tesamorelin

    The only GHRH analog FDA-approved today, and only to reduce excess belly fat in HIV lipodystrophy.

    Phase 3 RCTs in HIV lipodystrophy led to FDA approval; off-label populations less studied.

    5/5FDA approvedWADA bannedLab purity 99.35%
  2. Sermorelin

    The first 29 amino acids of natural GHRH. FDA-approved as Geref until it was withdrawn in 2008.

    Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older.

    4/5Not FDA approvedWADA bannedLab purity 99.28%
  3. CJC-1295 (no DAC) + Ipamorelin

    The classic GH-stimulating pair in one vial.

    Each component studied in humans for GH release; the combined long-term outcomes data is thin.

    3/5Not FDA approvedWADA bannedLab purity 99.52%
  4. Ipamorelin

    A selective growth-hormone secretagogue with a clean side-effect profile.

    Phase 2 human trials for postoperative ileus; GH-release effects are well documented in humans.

    3/5Not FDA approvedWADA bannedLab purity 99.71%
  5. IGF-1 LR3

    A long-acting lab version of IGF-1, the hormone growth hormone works through.

    Developed as a cell-culture reagent. No human clinical trials of LR3. Human data exists only for the approved native IGF-1 drug (mecasermin), a different product.

    1/5Not FDA approvedWADA bannedLab purity 99.25%

Ranked by human evidence (how we rate it), then FDA approval. Higher isn’t a recommendation to use anything.

Compare them head to head

Common questions

What is the best-researched peptide for growth hormone release?

Tesamorelin, rated 5/5 for human evidence: Phase 3 RCTs in HIV lipodystrophy led to FDA approval; off-label populations less studied.

Are any peptides for growth hormone release FDA approved?

Yes: Tesamorelin. The rest are not FDA approved for this use.

Which are banned in sport?

WADA bans Tesamorelin, Sermorelin, CJC-1295 (no DAC) + Ipamorelin, Ipamorelin, IGF-1 LR3.

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