Growth hormone peptides
5 peptides used for growth hormone release, ranked by how much human research backs each one. Status, lab purity and mixing math for every one. Educational, not medical advice.
Ranked by evidence
Tesamorelin
The only GHRH analog FDA-approved today, and only to reduce excess belly fat in HIV lipodystrophy.
Phase 3 RCTs in HIV lipodystrophy led to FDA approval; off-label populations less studied.
Sermorelin
The first 29 amino acids of natural GHRH. FDA-approved as Geref until it was withdrawn in 2008.
Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older.
CJC-1295 (no DAC) + Ipamorelin
The classic GH-stimulating pair in one vial.
Each component studied in humans for GH release; the combined long-term outcomes data is thin.
Ipamorelin
A selective growth-hormone secretagogue with a clean side-effect profile.
Phase 2 human trials for postoperative ileus; GH-release effects are well documented in humans.
IGF-1 LR3
A long-acting lab version of IGF-1, the hormone growth hormone works through.
Developed as a cell-culture reagent. No human clinical trials of LR3. Human data exists only for the approved native IGF-1 drug (mecasermin), a different product.
Ranked by human evidence (how we rate it), then FDA approval. Higher isn’t a recommendation to use anything.
Compare them head to head
- Ipamorelin vs Sermorelin
- Tesamorelin vs Sermorelin
- CJC-1295 (no DAC) + Ipamorelin vs Tesamorelin
- Ipamorelin vs CJC-1295 (no DAC) + Ipamorelin
- IGF-1 LR3 vs Ipamorelin
- Ipamorelin vs Tesamorelin
- CJC-1295 (no DAC) + Ipamorelin vs Sermorelin
- CJC-1295 (no DAC) + Ipamorelin vs IGF-1 LR3
- Tesamorelin vs IGF-1 LR3
- Sermorelin vs IGF-1 LR3
Common questions
What is the best-researched peptide for growth hormone release?
Tesamorelin, rated 5/5 for human evidence: Phase 3 RCTs in HIV lipodystrophy led to FDA approval; off-label populations less studied.
Are any peptides for growth hormone release FDA approved?
Yes: Tesamorelin. The rest are not FDA approved for this use.
Which are banned in sport?
WADA bans Tesamorelin, Sermorelin, CJC-1295 (no DAC) + Ipamorelin, Ipamorelin, IGF-1 LR3.
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