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A small angiotensin-derived compound with striking rat memory data and no human trials.
Last reviewed Oct 7, 2026 · How we rate evidence · Report an error
Dihexa is a small, drug-like molecule built from a fragment of angiotensin IV at Washington State University. In rats it reversed memory deficits in Alzheimer's-type models and grew new neuron connections. It has never been tested in a published human trial. It works by boosting a growth-factor system that is also involved in cancer, which is the main reason for caution.
Binds hepatocyte growth factor (HGF) and strengthens its signal through the c-Met receptor, promoting new synapses and dendritic spines. HGF/c-Met is also a well-known cancer-growth pathway.
Evidence
2/5
Animal and cell data from one main research group. No published human trials. A related HGF-boosting drug from the same lineage (fosgonimeton) missed its main goal in a Phase 2/3 Alzheimer's trial.
Half-life
Not established in humans
Known as
PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
Compare Dihexa with: SemaxAdamaxPinealonAdalankor any other →
Mostly animal dataMost of the evidence is from animal or cell studies, with tiny or uncontrolled human reports at most.
Animal and cell data from one main research group. No published human trials. A related HGF-boosting drug from the same lineage (fosgonimeton) missed its main goal in a Phase 2/3 Alzheimer's trial. How we rate evidence
Improved learning in rats with induced, Alzheimer's-like impairment.
Very potent at growing neuron connections in cell studies.
User reports; unverified.
“Anecdotal” means reported by users, not shown in controlled trials. Sources
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| Community Reported range 5–20 mg. No human dose has ever been tested. Many users start low and stay low. | 5 mg | Once daily | Short courses of a few weeks | Oral or transdermal (most common); some inject |
Set up for Dihexa. Switch vial size any time. Educational math only, not dosing advice.
Amino Club sells Dihexa as a research chemical. Its listings are research-use-only and not for human use; we show them for price tracking and their published lab reports.
Research-use-only listing — not for human use.
40% off through our link (code MYPEPSINFO applies automatically), until Dec 31, 2026.
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 10 mg | $35.99 | $3.60 | Out of stockNotify me | 99.54% pure, lot DHX0001 ILS Labs, tested Aug 3, 2026 |
List price, checked daily since Oct 7.
| Oct 7, 2026 | $59.99 | |
| Oct 8, 2026 | $59.99 | |
| Oct 9, 2026 | $59.99 | |
| Oct 10, 2026 | $59.99 | |
| Oct 11, 2026 | $59.99 | |
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| Oct 28, 2026 | $59.99 | |
| Oct 29, 2026 | $59.99 | |
| Oct 30, 2026 | $59.99 | |
| Oct 31, 2026 | $59.99 | |
| Nov 1, 2026 | $59.99 |
HPLC purity from each published lab report; lowest 99.54%.
| Aug 3, 2026 | 99.54% | lot DHX0001 |
Amino Club list prices as of Nov 1, 2026; sale prices include the 40% applied through our link. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the listing.
An email when it’s back in stock, its price drops, a sale starts, or its FDA or WADA status changes.
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All Dihexa lab reports, lot by lot →
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
Amazon affiliate links. Disclosure
Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~14 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
Never approved or tested in a registered human trial. It was in FDA compounding Category 2 until April 2026, when its nomination was withdrawn; an FDA advisory committee is due to review it by February 2027. Sold as a research chemical.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
That figure comes from one lab assay of neuron growth in a dish. It does not mean it works that way in a human brain.
It started from a peptide fragment but was redesigned into a small, fat-soluble molecule that can cross into the brain. It behaves more like a conventional drug.
Dihexa works by boosting HGF/c-Met signaling. That pathway is often overactive in tumors and helps them grow and spread. No study has shown Dihexa causes cancer, but none has ruled it out.
Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial. A common mix is 10 mg + 1 mL, which gives 10 mg/mL. Less water makes a stronger mix and fewer units per dose; more water makes a weaker mix and more units. Pick the amount that lands your dose on an easy-to-read line.
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light. Plan on about 14 days once it is mixed, and discard it sooner if it turns cloudy or has particles. The calculator shows how long a vial lasts at your dose and flags a vial that outlasts its shelf life.
Evidence rating (2/5): Animal and cell data from one main research group. No published human trials. A related HGF-boosting drug from the same lineage (fosgonimeton) missed its main goal in a Phase 2/3 Alzheimer's trial.
Legal status: Never approved or tested in a registered human trial. It was in FDA compounding Category 2 until April 2026, when its nomination was withdrawn; an FDA advisory committee is due to review it by February 2027. Sold as a research chemical.
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