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The first 29 amino acids of natural GHRH. FDA-approved as Geref until it was withdrawn in 2008.
Last reviewed Oct 7, 2026 · How we rate evidence · Report an error
Sermorelin, 29 amino acids, 3357.9 g/mol.
Sermorelin is the active front section of growth-hormone-releasing hormone (GHRH). It tells the pituitary to release its own growth hormone in natural pulses. It was sold as Geref in the US for growth-hormone deficiency in children, then discontinued in 2008 for business reasons, not safety. Today it is mainly prescribed through compounding pharmacies.
Binds the GHRH receptor on the pituitary, triggering a short pulse of growth hormone and a rise in IGF-1. The body's normal feedback (somatostatin) still applies, so levels stay within a more natural range than injected GH.
Evidence
4/5
Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older.
Half-life
About 10–20 minutes; the GH pulse lasts a few hours
Known as
Geref, GRF 1-29 NH2, Sermorelin acetate
Compare Sermorelin with: IpamorelinTesamorelinCJC-1295 (no DAC) + IpamorelinIGF-1 LR3or any other →
Strong human trialsLarge or multiple RCTs exist. It is not yet approved, approved outside the US, or approved only for a narrow use.
Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older. How we rate evidence
Reliable GH release shown in human studies.
Basis of its former FDA approval.
Some small trials and many user reports; results modest.
Leaner mass reported; controlled adult data is limited.
“Anecdotal” means reported by users, not shown in controlled trials. Sources
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| Community Range 200–500 mcg. Inject on an empty stomach; 5 days on / 2 off is common. | 300 mcg | Once daily at bedtime | 8–12 weeks or longer, with breaks | Subcutaneous |
Set up for Sermorelin. Switch vial size any time. Educational math only, not dosing advice.
At a common mix of 10 mg of Sermorelin in 5 mL of water (2 mg/mL), these commonly reported doses come to the following on a U-100 insulin syringe (100 units = 1 mL). They are examples of the arithmetic, not recommendations.
| Reported plan | Dose | Draw to | Volume |
|---|---|---|---|
| Community | 300 mcg | 15 units | 0.15 mL |
Concentration (mg/mL) = vial mg ÷ mL of water; units = dose (mg) ÷ concentration × 100. A different vial size or amount of water changes every number above.
Amino Club sells Sermorelin as a research chemical. Its listings are research-use-only and not for human use; we show them for price tracking and their published lab reports.
Research-use-only listing — not for human use.
40% off through our link (code MYPEPSINFO applies automatically), until Dec 31, 2026.
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 10 mg | $35.99 | $3.60 | In stock | 99.41% pure, lot SER0002 ILS Labs, tested Oct 22, 2026 |
List price, checked daily since Oct 7.
| Oct 7, 2026 | $59.99 | |
| Oct 8, 2026 | $59.99 | |
| Oct 9, 2026 | $59.99 | |
| Oct 10, 2026 | $59.99 | |
| Oct 11, 2026 | $59.99 | |
| Oct 12, 2026 | $59.99 | |
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| Oct 17, 2026 | $59.99 | |
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| Oct 19, 2026 | $59.99 | |
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| Oct 21, 2026 | $59.99 | |
| Oct 22, 2026 | $59.99 | |
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| Oct 25, 2026 | $59.99 | |
| Oct 26, 2026 | $59.99 | |
| Oct 27, 2026 | $59.99 | |
| Oct 28, 2026 | $59.99 | |
| Oct 29, 2026 | $59.99 | |
| Oct 30, 2026 | $59.99 | |
| Oct 31, 2026 | $59.99 | |
| Nov 1, 2026 | $59.99 |
HPLC purity from each published lab report; lowest 99.15%.
| Aug 3, 2026 | 99.15% | lot SER0001 |
| Oct 22, 2026 | 99.41% | lot SER0002 |
Amino Club list prices as of Nov 1, 2026; sale prices include the 40% applied through our link. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the listing.
An email when it’s back in stock, its price drops, a sale starts, or its FDA or WADA status changes.
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All Sermorelin lab reports, lot by lot →
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
Amazon affiliate links. Disclosure
Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~21 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
Geref was approved for growth-hormone deficiency in children. EMD Serono stopped making it in 2008, and FDA confirmed the withdrawal was not for safety or effectiveness. There is no approved brand on the market now. Compounding pharmacies can prepare it with a prescription; compounding rules change, so check the FDA's current bulk-substance lists. Research vials are not the approved drug.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
No. The maker stopped selling it in 2008 as recombinant GH took over the market. FDA stated the withdrawal was not due to safety or effectiveness.
Both are versions of the same 29-amino-acid GHRH fragment. CJC-1295 no-DAC (Mod GRF 1-29) has four swaps that make it last a bit longer. Sermorelin is the unmodified original with the longer human track record.
The body's biggest natural GH pulse happens in early deep sleep. A fasted bedtime dose is meant to boost that pulse.
It depends on the mix. At a common mix of 10 mg of Sermorelin in 5 mL of water (2 mg/mL), 300 mcg is 15 units (0.15 mL) on a U-100 insulin syringe. The formula is dose in mg ÷ concentration in mg/mL × 100. Change the vial size or water in the calculator and the units update. This is math, not a dose recommendation.
Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial. A common mix is 10 mg + 5 mL, which gives 2 mg/mL. Less water makes a stronger mix and fewer units per dose; more water makes a weaker mix and more units. Pick the amount that lands your dose on an easy-to-read line.
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light. Plan on about 21 days once it is mixed, and discard it sooner if it turns cloudy or has particles. The calculator shows how long a vial lasts at your dose and flags a vial that outlasts its shelf life.
Evidence rating (4/5): Human trials supported its former approval for pediatric GH deficiency. Evidence for adult anti-aging use is small and older.
Legal status: Geref was approved for growth-hormone deficiency in children. EMD Serono stopped making it in 2008, and FDA confirmed the withdrawal was not for safety or effectiveness. There is no approved brand on the market now. Compounding pharmacies can prepare it with a prescription; compounding rules change, so check the FDA's current bulk-substance lists. Research vials are not the approved drug.
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