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A 28-amino-acid neuropeptide that relaxes blood vessels and calms inflammation.
Last reviewed Oct 7, 2026 · How we rate evidence · Report an error
VIP is a natural hormone found in the gut, lungs and brain. It widens blood vessels, relaxes airways and calms immune responses. Synthetic VIP (aviptadil) is approved in the UK, mixed with phentolamine, as an injection for erectile dysfunction. Trials in COVID respiratory failure did not show benefit. Wellness use, mostly as a nasal spray for mold-related illness (CIRS), rests on small uncontrolled reports.
Binds VPAC1 and VPAC2 receptors. That relaxes smooth muscle in vessels and airways, reduces inflammatory cytokines and shifts immune cells toward a calmer profile. It breaks down within minutes in the blood.
Evidence
3/5
Real human data (ED approval in the UK, small lung studies, a large COVID RCT that failed). CIRS nasal use is small open-label work only.
Half-life
About 2 minutes in blood
Known as
Vasoactive intestinal peptide, Aviptadil, Zyesami
Compare VIP with: KPVThymosin Alpha-1LL-37or any other →
Some human dataSmall or older human trials, or bigger trials with mixed or negative results.
Real human data (ED approval in the UK, small lung studies, a large COVID RCT that failed). CIRS nasal use is small open-label work only. How we rate evidence
Injected with phentolamine into the penis, it is a licensed second-line ED treatment in the UK.
A small open-label study of inhaled VIP reported reduced airway inflammation markers.
Not a benefit: in the TESICO RCT (2023), IV aviptadil did not improve recovery or survival vs placebo.
Nasal VIP is used in the Shoemaker protocol. Support comes from small uncontrolled studies and user reports.
“Anecdotal” means reported by users, not shown in controlled trials. Sources
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| Community nasal (CIRS protocol) Typically a compounded nasal spray, not a mixed vial. | 50 mcg | Up to 4× daily | 1+ months under clinician supervision | Intranasal (spray) |
| Community subcutaneous Less established than the nasal route. | 100 mcg | Once daily | 2–4 weeks | Subcutaneous |
Set up for VIP. Switch vial size any time. Educational math only, not dosing advice.
At a common mix of 10 mg of VIP in 5 mL of water (2 mg/mL), these commonly reported doses come to the following on a U-100 insulin syringe (100 units = 1 mL). They are examples of the arithmetic, not recommendations.
| Reported plan | Dose | Draw to | Volume |
|---|---|---|---|
| Community nasal (CIRS protocol) Under 5 units is hard to measure accurately. Add more diluent for an easier draw. | 50 mcg | 2.5 units | 0.025 mL |
| Community subcutaneous | 100 mcg | 5 units | 0.05 mL |
Concentration (mg/mL) = vial mg ÷ mL of water; units = dose (mg) ÷ concentration × 100. A different vial size or amount of water changes every number above.
Amino Club sells VIP as a research chemical. Its listings are research-use-only and not for human use; we show them for price tracking and their published lab reports.
Research-use-only listing — not for human use.
40% off through our link (code MYPEPSINFO applies automatically), until Dec 31, 2026.
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 10 mg | $29.99 | $3.00 | In stock | 99.90% pure, lot VIP0002 ILS Labs, tested Oct 22, 2026 |
List price, checked daily since Oct 7.
| Oct 7, 2026 | $49.99 | |
| Oct 8, 2026 | $49.99 | |
| Oct 9, 2026 | $49.99 | |
| Oct 10, 2026 | $49.99 | |
| Oct 11, 2026 | $49.99 | |
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| Oct 17, 2026 | $49.99 | |
| Oct 18, 2026 | $49.99 | |
| Oct 19, 2026 | $49.99 | |
| Oct 20, 2026 | $49.99 | |
| Oct 21, 2026 | $49.99 | |
| Oct 22, 2026 | $49.99 | |
| Oct 23, 2026 | $49.99 | |
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| Oct 26, 2026 | $49.99 | |
| Oct 27, 2026 | $49.99 | |
| Oct 28, 2026 | $49.99 | |
| Oct 29, 2026 | $49.99 | |
| Oct 30, 2026 | $49.99 | |
| Oct 31, 2026 | $49.99 | |
| Nov 1, 2026 | $49.99 |
HPLC purity from each published lab report; lowest 99.60%.
| Aug 3, 2026 | 99.60% | lot VIP0001 |
| Oct 22, 2026 | 99.90% | lot VIP0002 |
Amino Club list prices as of Nov 1, 2026; sale prices include the 40% applied through our link. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the listing.
An email when it’s back in stock, its price drops, a sale starts, or its FDA or WADA status changes.
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All VIP lab reports, lot by lot →
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
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Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~14 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
No VIP or aviptadil product is FDA-approved. FDA declined emergency use authorization for IV aviptadil (Zyesami) in critical COVID-19, and the NIH-sponsored TESICO trial stopped its aviptadil arm for futility. It has been studied under orphan programs for lung disease. Compounded nasal VIP is used by some US clinicians; check current FDA compounding rules.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
It breaks down in about 2 minutes in blood. The CIRS protocol uses a nasal spray, and most user reports come from that route.
Yes, but only as aviptadil mixed with phentolamine for erectile dysfunction in the UK and some EU countries. Not in the US.
No. A large placebo-controlled trial found no benefit on recovery or survival.
It depends on the mix. At a common mix of 10 mg of VIP in 5 mL of water (2 mg/mL), 50 mcg is 2.5 units (0.025 mL) on a U-100 insulin syringe. The formula is dose in mg ÷ concentration in mg/mL × 100. Change the vial size or water in the calculator and the units update. This is math, not a dose recommendation.
Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial. A common mix is 10 mg + 5 mL, which gives 2 mg/mL. Less water makes a stronger mix and fewer units per dose; more water makes a weaker mix and more units. Pick the amount that lands your dose on an easy-to-read line.
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light. Plan on about 14 days once it is mixed, and discard it sooner if it turns cloudy or has particles. The calculator shows how long a vial lasts at your dose and flags a vial that outlasts its shelf life.
Evidence rating (3/5): Real human data (ED approval in the UK, small lung studies, a large COVID RCT that failed). CIRS nasal use is small open-label work only.
Legal status: No VIP or aviptadil product is FDA-approved. FDA declined emergency use authorization for IV aviptadil (Zyesami) in critical COVID-19, and the NIH-sponsored TESICO trial stopped its aviptadil arm for futility. It has been studied under orphan programs for lung disease. Compounded nasal VIP is used by some US clinicians; check current FDA compounding rules.
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