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The body's main antioxidant — popular for skin lightening, with thin evidence for it.
Last reviewed Oct 7, 2026 · How we rate evidence · Report an error
Glutathione is a three-amino-acid peptide every cell makes on its own. It is the body's main internal antioxidant and helps the liver clear toxins. It is sold as oral supplements, IV drips and injections, mostly for 'skin brightening'. A few small trials show modest lightening, but results are inconsistent and no regulator has approved it for that use.
Its cysteine thiol (-SH) group neutralizes reactive oxygen species and recycles other antioxidants. For skin, it is thought to shift melanin production from dark eumelanin toward lighter pheomelanin and to inhibit tyrosinase, the enzyme that starts melanin synthesis. How much of an injected dose reaches skin cells is unclear — it is broken down quickly in blood.
Evidence
3/5
A handful of small human trials (mostly oral, a few IV) with modest, inconsistent skin-lightening results. Well-studied as a natural molecule, but not as a cosmetic drug.
Half-life
Very short in blood after IV (minutes); levels return to baseline quickly
Known as
GSH, Reduced glutathione, L-Glutathione, γ-Glutamyl-cysteinyl-glycine
Compare Glutathione with: NAD+GHK-CuGLOWor any other →
Some human dataSmall or older human trials, or bigger trials with mixed or negative results.
A handful of small human trials (mostly oral, a few IV) with modest, inconsistent skin-lightening results. Well-studied as a natural molecule, but not as a cosmetic drug. How we rate evidence
Small oral and IV trials report modest lightening in some people; effects fade after stopping and studies are short and small.
Raises glutathione levels in blood in some supplement studies; whether that changes health outcomes is unproven.
Studied as an add-on to cisplatin-type chemotherapy to reduce nerve damage, with mixed results.
Users of IV drips often report feeling better; no controlled evidence for this.
“Anecdotal” means reported by users, not shown in controlled trials. Sources
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| Community (IM / SC) Figures of 100–600 mg per injection are cited; 100–200 mg is a common starting range. Large volume — often split or given IM. | 150 mg | 1–3× per week | 4–8 weeks | Intramuscular or subcutaneous |
| IV push (clinic) 600–1200 mg slow IV is typical in clinics. IV should only be done by trained staff — not self-administered. | 600 mg | 1–2× per week | Course of several weeks | Intravenous |
| Oral supplement Trials used roughly 250–1000 mg per day. Not a calculator dose — follow the product label. | – | Daily | 8–12 weeks in studies | Oral |
Set up for Glutathione. Switch vial size any time. Educational math only, not dosing advice.
At a common mix of 1,500 mg of Glutathione in 10 mL of water (150 mg/mL), these commonly reported doses come to the following on a U-100 insulin syringe (100 units = 1 mL). They are examples of the arithmetic, not recommendations.
| Reported plan | Dose | Draw to | Volume |
|---|---|---|---|
| Community (IM / SC) | 150 mg | 100 units | 1 mL |
Concentration (mg/mL) = vial mg ÷ mL of water; units = dose (mg) ÷ concentration × 100. A different vial size or amount of water changes every number above.
Amino Club sells Glutathione as a research chemical. Its listings are research-use-only and not for human use; we show them for price tracking and their published lab reports.
Research-use-only listing — not for human use.
40% off through our link (code MYPEPSINFO applies automatically), until Dec 31, 2026.
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 1500 mg | $35.99 | $0.02 | Out of stockNotify me | 99.41% pure, lot GLT0003 ILS Labs, tested Aug 20, 2026 |
List price, checked daily since Oct 7.
| Oct 7, 2026 | $59.99 | |
| Oct 8, 2026 | $59.99 | |
| Oct 9, 2026 | $59.99 | |
| Oct 10, 2026 | $59.99 | |
| Oct 11, 2026 | $59.99 | |
| Oct 12, 2026 | $59.99 | |
| Oct 13, 2026 | $59.99 | |
| Oct 14, 2026 | $59.99 | |
| Oct 15, 2026 | $59.99 | |
| Oct 16, 2026 | $59.99 | |
| Oct 17, 2026 | $59.99 | |
| Oct 18, 2026 | $59.99 | |
| Oct 19, 2026 | $59.99 | |
| Oct 20, 2026 | $59.99 | |
| Oct 21, 2026 | $59.99 | |
| Oct 22, 2026 | $59.99 | |
| Oct 23, 2026 | $59.99 | |
| Oct 24, 2026 | $59.99 | |
| Oct 25, 2026 | $59.99 | |
| Oct 26, 2026 | $59.99 | |
| Oct 27, 2026 | $59.99 | |
| Oct 28, 2026 | $59.99 | |
| Oct 29, 2026 | $59.99 | |
| Oct 30, 2026 | $59.99 | |
| Oct 31, 2026 | $59.99 | |
| Nov 1, 2026 | $59.99 |
HPLC purity from each published lab report; lowest 99.38%.
| May 29, 2026 | 99.96% | lot GLT0001 |
| Jul 30, 2026 | 99.38% | lot GLT0002 |
| Aug 20, 2026 | 99.41% | lot GLT0003 |
Amino Club list prices as of Nov 1, 2026; sale prices include the 40% applied through our link. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the listing.
An email when it’s back in stock, its price drops, a sale starts, or its FDA or WADA status changes.
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All Glutathione lab reports, lot by lot →
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
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Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~14 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
There is no FDA-approved glutathione drug product in the US. Oral glutathione is sold as a dietary supplement, and injectable glutathione is prepared by compounding pharmacies. No glutathione product is approved anywhere for skin lightening.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
Some small trials show a modest effect in some people, and it fades after stopping. It is far from guaranteed, and no regulator has approved it for this.
IV reaches higher blood levels briefly, but glutathione is broken down within minutes. There is no good head-to-head evidence that one route works better for skin.
Glutathione is a small, natural molecule used at much higher amounts than signaling peptides — hundreds of milligrams per dose, not hundreds of micrograms.
It depends on the mix. At a common mix of 1,500 mg of Glutathione in 10 mL of water (150 mg/mL), 150 mg is 100 units (1 mL) on a U-100 insulin syringe. The formula is dose in mg ÷ concentration in mg/mL × 100. Change the vial size or water in the calculator and the units update. This is math, not a dose recommendation.
Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial. A common mix is 1,500 mg + 10 mL, which gives 150 mg/mL. Less water makes a stronger mix and fewer units per dose; more water makes a weaker mix and more units. Pick the amount that lands your dose on an easy-to-read line.
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light. Plan on about 14 days once it is mixed, and discard it sooner if it turns cloudy or has particles. The calculator shows how long a vial lasts at your dose and flags a vial that outlasts its shelf life.
Evidence rating (3/5): A handful of small human trials (mostly oral, a few IV) with modest, inconsistent skin-lightening results. Well-studied as a natural molecule, but not as a cosmetic drug.
Legal status: There is no FDA-approved glutathione drug product in the US. Oral glutathione is sold as a dietary supplement, and injectable glutathione is prepared by compounding pharmacies. No glutathione product is approved anywhere for skin lightening.
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