Recent discoveries in MOTS-c benefits | The Peps Report

Show notes

Mark and Amy walk through the latest MOTS-c research: a mitochondria-derived peptide studied for insulin sensitivity, exercise capacity, heart damage from sepsis, egg-cell energy in aging, and tissue transplants. They keep one point front and center: most of it is still animal and lab work, and MyPeps rates the evidence at 2 out of 5.

Peptides covered

MOTS-c

Free tools

Free reconstitution and dosing calculator: mypeps.info/calculator

Sources

Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review — Physiology International, Aug 2026. https://pubmed.ncbi.nlm.nih.gov/42640735/
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential — European Journal of Pharmacology, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42633878/
The Mitochondrial-Derived Peptide MOTS-c Improves Bioenergetics in Aging-Associated Granulosa Cells and Oocytes — Reproduction & Fertility, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42895211/
Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility — Tissue & Cell, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42880137/
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming — Bioactive Materials, Aug 2026. https://pubmed.ncbi.nlm.nih.gov/42633281/
MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation — Autophagy, Oct 2026. https://pubmed.ncbi.nlm.nih.gov/42153537/

Where we buy

Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission.

Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs.