Mark and Amy dig into a new review of peptides used in urology and sexual medicine. Out of 76 studies, only two peptides, PT-141 and tesamorelin, have defined dosing and an approved use, and both approvals are narrow. They also look at why raising IGF-1 isn't the same as a proven benefit, where kisspeptin and testosterone therapy overlap and split, a new mouse study on kisspeptin and estrogen, and a large records study of GLP-1 drugs before pregnancy in PCOS.
In this episode
- 00:00 Theme, cold open and intro
- 00:54 Grocery-store reading
- 01:05 The new urology review: only two peptides with approved uses
- 03:34 The flip side: unregulated markets and the review's limits
- 04:29 Where kisspeptin and testosterone overlap and split
- 05:19 Quick hits: kisspeptin in mice, GLP-1 drugs and PCOS
- 06:09 Fine print and what it means for you
- 06:23 Bottom line
- 06:45 Wrap-up and Amino Club code
Peptides covered
Free tools
- Free reconstitution and dosing calculator: mypeps.info/calculator
Sources
- Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review — Sexual Medicine Reviews, Sep. 30, 2026. https://pubmed.ncbi.nlm.nih.gov/42862021/
- VYLEESI (bremelanotide injection) prescribing information — U.S. Food and Drug Administration, June 2019. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf
- EGRIFTA (tesamorelin for injection) prescribing information — U.S. Food and Drug Administration, 2012. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022505s004lbl.pdf
- Drug scheduling — U.S. Drug Enforcement Administration. https://www.dea.gov/drug-information/drug-scheduling
- World Anti-Doping Code International Standard: Prohibited List 2026 — World Anti-Doping Agency, Jan. 1, 2026. https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf
- Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice — Journal of Neuroendocrinology, Oct. 2026. https://pubmed.ncbi.nlm.nih.gov/42833261/
- Preconception incretin therapy reduces pregnancy and cardiometabolic outcomes in polycystic ovary syndrome — Journal of Clinical Endocrinology & Metabolism, Oct. 10, 2026. https://pubmed.ncbi.nlm.nih.gov/42857939/
Where we buy
Amino Club publishes an independent lab report (COA) for every lot; see them on our lab reports page. Their products are sold for research use only, not for human use: aminoclub.com, 40% off with code MYPEPSINFO. This is an affiliate link, so we may earn a commission.
Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs. Mark and Amy are AI-generated voices; every episode is reviewed by our editor, Ryan E., MS.