Nicholas ranks twelve of the most-discussed peptides on the MyPeps 1–5 evidence scale, from approved drugs with huge trials to compounds with almost no human data, and explains what the score does and doesn't tell you.
Read the full post: The most-researched peptides of 2026, ranked by evidence
In this episode
- 00:00 Cold open and intro
- 00:40 How the 1-to-5 evidence scale works
- 01:03 Level 5: semaglutide, tirzepatide, tesamorelin
- 01:32 Level 4: retatrutide, cagrilintide, PT-141, thymosin alpha-1
- 02:02 Levels 3 to 1: GHK-Cu, AOD-9604, BPC-157, TB-500, IGF-1 LR3
- 02:29 Why evidence levels matter for you
- 03:03 What the ranking does and doesn't tell you
- 03:23 Wrap-up and Amino Club code
Peptides covered
- Semaglutide
- Tirzepatide
- Tesamorelin
- Retatrutide
- Cagrilintide
- PT-141
- Thymosin alpha-1
- GHK-Cu
- AOD-9604
- BPC-157
- TB-500
- IGF-1 LR3
Tools and deals
- Free reconstitution and dosing calculator: mypeps.info/calculator
- Amino Club: 40% off with code MYPEPSINFO at aminoclub.com
Sources
- https://www.nejm.org/doi/full/10.1056/NEJMoa2032183
- https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
- https://www.nejm.org/doi/full/10.1056/NEJMoa2416394
- https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
- https://www.fda.gov/media/193343/download
- Full source list in the blog post.
Educational information only, not medical advice. Talk to a licensed clinician before starting, stopping or changing any medication. Research-grade peptides are not FDA-approved drugs.